The short version
The TESICO randomized trial did not find a significant improvement in 90-day outcomes with intravenous aviptadil in severe COVID-19. This negative result concerns hospitalized respiratory failure and does not establish effects of other routes or indications.
An investigational profile is not an endorsement or a finding of safety.
Names you may see
Compound names, research identifiers, brand names and informal shorthand serve different purposes.
- VIP
- Entry name · The name used for this encyclopedia topic.
No additional name variations have been documented for this entry yet. This is not a claim that none exist.
Similar names do not establish identical ingredients, molecular variants, product quality or interchangeable preparations. A blend nickname may describe different formulas.
Things worth checking
What does this source leave unanswered?
This negative result concerns hospitalized respiratory failure and does not establish effects of other routes or indications.
Limits of the selected research · Selected original research abstract ↗
Questions to bring to a clinician or pharmacist
- Which findings apply to my goal and medical history?
- Could my medicines, supplements, or other compounds change the assessment?
- What monitoring, if any, would inform a decision—and what symptoms would need evaluation?
Monitoring is individual. Normal bloodwork does not establish that a compound or preparation is safe.
Delivery methods
How a compound is delivered can change the question being studied. These selected examples explain the route, purpose and evidence limits; they do not establish an appropriate route for an individual.
Intravenous aviptadil, a synthetic VIP preparation
Human research; randomized, placebo-controlled, multicentre tesico trial
- Why it was studied or discussed
- The route used in this selected study; this is research context, not instructions.
- What this means for the reader
- This negative result concerns hospitalized respiratory failure and does not establish effects of other routes or indications.
This is a selected comparison, not an exhaustive list of preparations or a guide to administering them. The clinical summaries below identify the route used in each study.
Clinical research
A selected human study is summarized below. Its design and preparation limit what can be inferred.
Intravenous aviptadil and remdesivir for treatment of COVID-19-associated hypoxaemic respiratory failure in the USA (TESICO): a randomised, placebo-controlled trial.
Summary based on: Published abstract, retrieved through Europe PMC; full text not appraised
- Study design
- Randomized, placebo-controlled, multicentre TESICO trial
- Who was studied
- 461 participants received at least part of aviptadil or placebo; severe COVID-19 respiratory failure
- Route and preparation
- Intravenous aviptadil, a synthetic VIP preparation
- What was compared
- Aviptadil versus matched placebo; 90-day clinical outcomes
- What researchers found
- The TESICO randomized trial did not find a significant improvement in 90-day outcomes with intravenous aviptadil in severe COVID-19.
- What this leaves unanswered
- This negative result concerns hospitalized respiratory failure and does not establish effects of other routes or indications.
Research terms in everyday language ↗
This overview covers the selected published abstract, retrieved through Europe PMC. Full-text appraisal and a comprehensive literature review are not complete; omitted studies are a coverage gap, not evidence that they do not exist.
Read findings in the context of the exact product or preparation, the people studied, and the outcome measured. These draft profiles are starting points, rather than complete systematic reviews.
Community research
Structured community reports can help identify questions worth studying. They are considered separately from controlled studies, with their limitations kept visible.
No community reports published yet.
This profile has no published community dataset. We do not infer a trend or a benefit from missing reports.
How community research will work ↗What we will document about community advice
- The advice
- What people recommend, with dated sources and the scope of the discussions examined.
- The reasoning
- Why contributors believe it helps, without treating that explanation as an established mechanism.
- The evidence
- What supports the claim, contradicts it, or has not been tested.
- The cautions
- Possible downsides, conflicting experiences, and questions for a clinician or pharmacist.
No recommendation or community consensus is established by this framework. Descriptions of how common advice is will need documented source coverage.
A closer look
- Classification
- Vasoactive intestinal peptide is a signaling peptide; aviptadil is a synthetic form studied in specific clinical settings.
- Name variations
- Names you may see and important distinctions
- Source type
- Original research · published abstract
- Reference jurisdiction
- Research setting; approval status is product- and country-specific
Interpret the source in the context of the preparation and route it discusses. A regulatory notice and a controlled clinical trial answer different questions.
This first design edition reserves space for study-by-study summaries, definitions, and technical references as each profile receives editorial review.
Go to the source
Study cards identify whether the summary uses an abstract, full text, or an agency assessment. Follow the linked sources for their original context.
Source reference · Checked 8 November 2026 · Opens in a new tab
For athletes: competition rules are a separate check ↗